期刊
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
卷 13, 期 -, 页码 359-370出版社
CELL PRESS
DOI: 10.1016/j.omtm.2019.02.008
关键词
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资金
- National Natural Science Foundation of China [81672982, 81602670]
- Sichuan Provincial Research Foundation for Basic Research [18YYJC1284]
The expanding CRISPR-Cas9 technology is an easily accessible, programmable, and precise gene-editing tool with numerous applications, most notably in biomedical research. Together with advancements in genome and transcriptome sequencing in the era of metadata, genomic engineering with CRISPR-Cas9 meets the developmental requirements of precision medicine, and clinical tests using CRISPR-Cas9 are now possible. This review summarizes developments and established preclinical applications of CRISPR-Cas9 technology, along with its current challenges, and highlights future applications in translational research.
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