期刊
CANCER MANAGEMENT AND RESEARCH
卷 11, 期 -, 页码 1321-1336出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S187780
关键词
head and neck malignancy; gene mutations; deletions; amplifications; genetic interactions; target therapy
类别
资金
- Medical Health Science and Technology Project of Zhejiang Provincial Health Commission [2014KYB129]
- Zhejiang Provincial Natural Science Foundation of China [LY15H160028]
Head and neck squamous cell carcinoma (HNSCC) is highly variable by tumor site, histologic type, molecular characteristics, and clinical outcome. During recent years, emerging targeted therapies have been focused on driver genes. HNSCC involves several genetic alterations, such as co-occurrence, multiple feedback loops, and cross-talk communications. These different kinds of genetic alterations interact with each other and mediate targeted therapy response. In the current review, it is emphasized that future treatment strategy in HNSCC will not solely be based on synthetic lethality approaches directed against overactivated genes. More importantly, biologic, genetic, and epigenetic alterations of HNSCC will be taken into consideration to guide the therapy. The emerging genetic alterations in HNSCC and its effect on targeted therapy response are discussed in detail. Hopefully, novel combination regimens for the treatment of HNSCC can be developed.
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