期刊
INFECTIOUS DISEASES
卷 51, 期 4, 页码 287-292出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/23744235.2018.1533646
关键词
Prosthetic valve endocarditis; vancomycin-intermediate S; aureus; time-kill study
Infectious complications following surgical valve replacements are extremely difficult to treat, often requiring prolonged antimicrobials therapy with or without surgery. Vancomycin-intermediate Staphylococcus aureus is an infrequent pathogen, with an estimated prevalence of less than 0.3%, but presents even greater challenges. We report a case of successful cure of daptomycin-non-susceptible and vancomycin-intermediate Staphylococcus aureus prosthetic valve endocarditis using an eight-week course of combination antimicrobial therapy. Using time-kill study, the combination of daptomycin plus ceftaroline and rifampin resulted in a greater than 4 log reduction of bacterial growth at 24 hours. This antimicrobial combination was used for a total of eight weeks with a successful outcome.
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