Silk-Enabled Conformal Multifunctional Bioelectronics for Investigation of Spatiotemporal Epileptiform Activities and Multimodal Neural Encoding/Decoding

Flexible electronics can serve as powerful tools for biomedical diagnosis and therapies of neurological disorders, particularly for application cases with brain-machine interfaces (BMIs). Existing conformal soft bioelectrodes are applicable for basic electrocorticogram (ECoG) collecting/monitoring. Nevertheless, as an emerging and promising approach, further multidisciplinary efforts are still demanded for in-depth exploitations with these conformal soft electronics toward their practical neurophysiological applications in both scientific research and real-world clinical operation. Here, clinically-friendly silk-supported/delivered soft bioelectronics are developed, and multiple functions and features valuable for customizable intracranial applications (e.g., biocompatible and spontaneously conformal coupling with cortical surface, spatiotemporal ECoG detecting/monitoring, electro-neurophysiological neural stimulating/decoding, controllable loading/delivery of therapeutic molecules, and parallel optical readouts of operating states) are integrated.