期刊
NANOMATERIALS
卷 9, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/nano9030462
关键词
electrospun hybrid mats; ultrasound assisted extraction; anti-infective wound dressing; poly-epsilon-caprolactone; gelatin
类别
资金
- Lee Kong Chian School of Medicine, Nanyang Technological University Singapore Start-Up Grant [L0412290]
- Strategic Academic Initiative Grant [SAI-L0494003]
- Industry Alignment Fund Pre-Positioning Grant [IAF-PP H17/01/a0/0K9]
- UGC-DAE Consortium for Scientific Research Kalpakkam, Tamilnadu, India [CSR-KN/CRS-70/2015-16/811]
- Translational and Clinical Research Flagship Program of the Singapore National Research Foundation [NMRC/TCR/008-SERI/2013]
- Co-operative Basic Research Grant from the Singapore NMRC [NMRC/CBRG/0048/2013]
- SNEC Ophthalmic Technologies Incubator Program grant [R1181/83/2014]
- Nanyang Technological University Singapore Start-Up Grant [L0412290]
Electrospun fibers have emerged as promising materials in the field of biomedicine, due to their superior physical and cell supportive properties. In particular, electrospun mats are being developed for advanced wound dressing applications. Such applications require the firers to possess excellent antimicrobial properties in order to inhibit potential microbial colonization from resident and non-resident bacteria. In this study, we have developed Poly-epsilon-Caprolactone /gelatin hybrid composite mats loaded with natural herbal extract (Gymnema sylvestre) to prevent bacterial colonization. As-spun scaffolds exhibited good wettability and desirable mechanical properties retaining their fibrous structure after immersing them in phosphate buffered saline (pH 7.2) for up to 30 days. The initial burst release of Gymnema sylvestre prevented the colonization of bacteria as confirmed by the radial disc diffusion assay. Furthermore, the electrospun mats promoted cellular attachment, spreading and proliferation of human primary dermal fibroblasts and cultured keratinocytes, which are crucial parenchymal cell-types involved in the skin recovery process. Overall these results demonstrated the utility of Gymnema sylvestre impregnated electrospun PCL/Gelatin nanofibrous mats as an effective antimicrobial wound dressing.
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