期刊
NANOMATERIALS
卷 9, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nano9020224
关键词
interstitial cystitis/bladder pain syndrome (IC/BPS); ZnO nanorods; surface enhancement Raman spectroscopy (SERS); principal component analysis (PCA)
类别
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science ICT (MSIT) [2018R1D1A1B07048562]
- MRC through the National Research Foundation of Korea (NRF) - Ministry of Science ICT (MSIT) [2018R1A5A2020732]
- Ministry of Trade, Industry & Energy (MOTIE) under the Industrial Technology Innovation Program [10080726, 20000843]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI)
- Ministry of Health & Welfare, Republic of Korea [HI18C2391]
- National Research Foundation of Korea [2018R1D1A1B07048562] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
To evaluate the feasibility of ZnO nanorod-based surface enhanced Raman scattering (SERS) diagnostics for disease models, particularly for interstitial cystitis/bladder pain syndrome (IC/BPS), ZnO-based SERS sensing chips were developed and applied to an animal disease model. ZnO nanorods were grown to form nano-sized porous structures and coated with gold to facilitate size-selective biomarker detection. Raman spectra were acquired on a surface enhanced Raman substrate from the urine in a rat model of IC/BPS and analyzed using a statistical analysis method called principal component analysis (PCA). The nanorods grown after the ZnO seed deposition were 30 to 50 nm in diameter and 500 to 600 nm in length. A volume of gold corresponding to a thin film thickness of 100 nm was deposited on the grown nanorod structure. Raman spectroscopic signals were measured in the scattered region for nanometer biomarker detection to indicate IC/BPS. The Raman peaks for the control group and IC/BPS group are observed at 641, 683, 723, 873, 1002, 1030, and 1355 cm(-1),which corresponded to various bonding types and compounds. The PCA results are plotted in 2D and 3D. The Raman signals and statistical analyses obtained from the nano-sized biomarkers of intractable inflammatory diseases demonstrate the possibility of an early diagnosis.
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