期刊
FRONTIERS IN NEUROSCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2019.00255
关键词
Parkinson disease; tremor-dominant; iron metabolism; inflammation; IL-6
资金
- National Key Research and Development Program of China [2016YFC1306000, 2016YFC1306300]
- National Key R&D Program of China-European Commission [2017YFE0118800-779238]
- National Natural Science Foundation of China [81571229, 81071015, 30770745]
- Key Project of National Natural Science Foundation of China [81030062]
- Natural Science Foundation of Beijing, China [7082032]
- National Key Basic Research Program of China [2011CB504100]
- Important National Science & Technology Specific Projects [2011ZX09102-003-01]
- National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2013BAI09B03]
- Project of Scientific and Technological Development of Traditional Chinese Medicine in Beijing [JJ2018-48]
- Project of Beijing Institute for Brain Disorders [BIBD-PXM2013_014226_07_000084]
- High Level Technical Personnel Training Project of Beijing Health System, China [2009-3-26]
- Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality [IDHT20140514]
- Capital Clinical Characteristic Application Research [Z12110700100000, Z121107001012161]
- Beijing Healthcare Research Project, China [JING-15-2]
- Excellent Personnel Training Project of Beijing, China [20071D0300400076]
- Natural Science Foundation of Capital Medical University [PYZ2018077]
- Basic-Clinical Research Cooperation Funding of Capital Medical University, China [2015-JL-PT-X04, 10JL49, 14JL15]
- Capital Medical University, China [2015-YQN-15, 2015-YQN-14, 2015-YQN-17]
Background: Tremor is one of the most predominant symptoms of patients with Parkinson disease (PD), but the underlying mechanisms for tremor relating to iron and its metabolism-related proteins and the inflammatory factors in cerebrospinal fluid (CSF) and serum have not been fully elucidated. Methods: A total of 135 PD patients were divided into a tremor-dominant (PD-TD) group (N = 74) and a postural instability and gait difficulty-dominant (PD-PIGD) group (N = 39) based on the ratio of mean tremor score to the mean bradykinesia/rigid score of the Unified Parkinson's Disease Rating Scale (UPDRS) III. Age and sex-matched healthy controls were recruited (N = 35). Demographic variables were evaluated; iron and its metabolism-related proteins and the inflammatory mediators in both CSF and serum were measured in these groups. The relevance of iron metabolism, inflammation and PD-TD were analyzed. Results: (1) The PD-TD group had significantly decreased L-ferritin, increased iron levels in CSF and increased ferritin levels in the serum compared with the PD-PIGD and control groups (P < 0.05). (2) The PD-TD group had significantly enhanced IL-6 levels in both CSF and serum compared with the PD-PIGD and control groups (P < 0.05). (3) In CSF, the IL-6 level was increased as the iron level was elevated in the PD-TD group (r = 0.308, P = 0.022). In serum, the IL-6 level was increased as the ferritin level was elevated in the PD-TD group (r = 0.410, P = 0.004). Conclusion: The interplay between disturbed iron metabolism and relevant inflammation might modulate clinical phenotypes of PD.
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