期刊
FRONTIERS IN NEUROSCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2019.00238
关键词
NCOA4; ferritinophagy; iron homeostasis; ferroptosis; neurodegenerative disorders; neurodegenerative disease; neurodegeneration
资金
- Burroughs Wellcome Fund Career Award for Medical Scientists
- Brigham and Women's Hospital MFCD Award
- Sidney Kimmel Foundation Kimmel Scholar Program
- Dana-Farber Cancer Institute Claudia Adams Barr Program for Innovative Cancer Research Award
NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in intracellular and systemic iron homeostasis. Disruptions in iron homeostasis and autophagy are observed in several neurodegenerative disorders raising the possibility that NCOA4-mediated ferritinophagy links these two observations and may underlie, in part, the pathophysiology of neurodegeneration. Here, we review the available evidence detailing the molecular mechanisms of NCOA4-mediated ferritinophagy and recent studies examining its role in systemic iron homeostasis and erythropoiesis. We propose additional studies to examine the potential role of NCOA4 in the brain in the context of neurodegenerative diseases.
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