期刊
FEBS OPEN BIO
卷 9, 期 3, 页码 437-445出版社
WILEY
DOI: 10.1002/2211-5463.12597
关键词
AKT; apoptosis; breast cancer; Hippo; PTEN; YAP1
资金
- Medical Science and Technology Planning Project of Zhejiang Province [2016DTA002]
- Chinese Foundation for Hepatitis Prevention and Control-TianQing Liver Disease Research Fund Subject [TQGB20170140]
- Cultivation of High-level Innovation Health Talents of Zhejiang [2012-241]
YES-associated protein 1 (YAP1) plays a key role as a transcriptional coactivator in the Hippo tumor suppressor pathway. YAP1 is overexpressed in a variety of cancers and is considered to be encoded by a proto-oncogene. However, the role of YAP1 remains debatable, because both gain and loss of YAP1 expression have both been reported in breast cancer (BC). Here, we found that elevated expression of YAP1 mRNA in BC was negatively correlated with relapse-free, distant metastases-free and overall survival rates. We then knocked down or overexpressed YAP1 in human BC cells, and examined cell proliferation, apoptosis, and tumorigenic ability invivo. We identified that YAP1 promotes cell growth and inhibits cell apoptosis of BC through the phosphatase and tensin homolog deleted on chromosome 10-AKT signaling pathway, and thus suggest that YAP1 might serve as a new target for inhibiting BC progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据