期刊
CATALYSTS
卷 9, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/catal9040305
关键词
photooxidation; cascade; alcohol; reductive amination; omega-transaminase
资金
- European Research Council (ERC) [648026]
- European Research Council (ERC) [648026] Funding Source: European Research Council (ERC)
The consecutive photooxidation and reductive amination of various alcohols in a cascade reaction were realized by the combination of a photocatalyst and several enzymes. Whereas the photocatalyst (sodium anthraquinone-2-sulfonate) mediated the light-driven, aerobic oxidation of primary and secondary alcohols, the enzymes (various -transaminases) catalyzed the enantio-specific reductive amination of the intermediate aldehydes and ketones. The system worked in a one-pot one-step fashion, whereas the productivity was significantly improved by switching to a one-pot two-step procedure. A wide range of aliphatic and aromatic compounds was transformed into the enantiomerically pure corresponding amines via the photo-enzymatic cascade.
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