期刊
CATALYSTS
卷 9, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/catal9020167
关键词
cholesterol; coprostanol; reduction reaction; bacteria; metabolic pathways
资金
- Microbiology and the Food Chain division (MICA) of the INRA institute through the metaprogramme MEM-Meta-omics and microbial ecosystems
- project CMCU-PHC Utique-Campus France [14G0816, 30666QM]
The gut microbiota plays a key role in cholesterol metabolism, mainly through the reduction of cholesterol to coprostanol. The latter sterol exhibits distinct physicochemical properties linked to its limited absorption in the gut. Few bacteria were reported to reduce cholesterol into coprostanol. Three microbial pathways of coprostanol production were described based on the analysis of reaction intermediates. However, these metabolic pathways and their associated genes remain poorly studied. In this review, we shed light on the microbial metabolic pathways related to coprostanol synthesis. Moreover, we highlight current strategies and future directions to better characterize these microbial enzymes and pathways.
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