期刊
CANCER MEDICINE
卷 8, 期 4, 页码 1652-1654出版社
WILEY
DOI: 10.1002/cam4.2011
关键词
cancer resistance; Cretaceous-Paleogene boundary; Heterocephalus glaber; human cancer excess; human mutation rate; naked mole rat; Peto's paradox; rapid human evolution
类别
We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in living fossil' animals may help us find tools for cancer prevention and treatment.
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