期刊
ADVANCED MATERIALS INTERFACES
卷 6, 期 7, 页码 -出版社
WILEY
DOI: 10.1002/admi.201801814
关键词
colloidal stability; functionalization; metal oxide nanoparticles; phosphonic acids; surface coating
资金
- ANR (Agence Nationale de la Recherche)
- CGI (Commissariat a l'Investissement d'Avenir) [ANR 11 LABX 086, ANR 11 IDEX 05 02]
- French National Research Agency [ANR-10-INSB-04]
- Agence Nationale de la Recherche [ANR-13-BS08-0015, ANR-12-CHEX-0011, ANR-15-CE18-0024-01]
For applications in nanomedicine, particles need to be functionalized to prevent protein corona formation and/or aggregation. Most advanced strategies take advantage of functional polymers and assembly techniques. Nowadays there is an urgent need for coatings that are tailored according to a broad range of surfaces and that can be produced on a large scale. Herein, we synthesize monophosphonic and multiphosphonic acid based poly(ethylene glycol) (PEG) polymers with the objective of producing efficient coats for metal oxide nanoparticles. Cerium, iron, titanium, and aluminum oxide nanoparticles of different morphologies (spheres, platelets, nanoclusters) and sizes ranging from 7 to 40 nm are studied in physiological and in protein rich cell culture media. It is found that the particles coated with monofunctionalized polymers exhibit a mitigated stability over time (<1 week), whereas the multifunctionalized copolymers provide resilient coatings and long-term stability (> months). With the latter, PEG densities in the range 0.2-0.5 nm(-2) and layer thickness about 10 nm provide excellent performances. The study suggests that the proposed coating allows controlling nanomaterial interfacial properties in biological environments.
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