期刊
ACS PHOTONICS
卷 6, 期 2, 页码 501-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsphotonics.8b01470
关键词
hybrid metasurface; graphene; mid-infrared biosensor; tunable fingerprinting; secondary structure
类别
资金
- Defense Advanced Research Projects Agency Young Faculty Award [D15AP00111]
- Air Force Office of Scientific Research [FA9550-14-1-0389, FA9550-16-1-0322]
- National Science Foundation [ECCS-1307948]
- U.S. Department of Energy, Office of Basic Energy Sciences [DE-SC0012704]
Metasurfaces emerge as a promising photonic platform for biosensing because they offer strong optical confinement and tunable optical resonances. Here, we show that metasurface-based biosensors consisting of gold nano antenna arrays loaded with graphene and working in the mid infrared (mid-IR) spectral range can achieve simultaneous high-sensitivity and high-specificity detection of biomolecules. Strong light molecule interactions in deeply subwavelength optical spots created by the biosensors allow us to determine the concentration of protein molecules via spectral shifts of the metasurface resonance. A combination of passive and active tuning of the metasurface sensors allows us to spectrally overlap the metasurface resonance and the protein vibrational modes, so that protein molecules can be identified via their characteristic mid-IR fingerprints. The high sensitivity and specificity of the metasurface sensors enable us to determine the secondary structure of protein immunoglobulin (IgG) molecules 4 orders of magnitude more sensitive than attenuated total reflection Fourier transform infrared spectroscopy.
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