期刊
TRANSLATIONAL PSYCHIATRY
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41398-019-0433-6
关键词
-
类别
资金
- European Union [LSHM-CT-2007-037286]
- Agence Nationale de la Recherche ANR [AF12-NEUR0008-01-WM2NA, ANR-12-SAMA-0004]
- Fondation de France [2012-00033703, 2017-0008L242]
- Fondation pour la Recherche Medicale [DPA20140629802, DPP20151033945]
- Federation pour la Recherche sur le Cerveau (AAP 2014)
- Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA)
- INSERM
- Academy of Finland [276612]
- Emil Aaltonen Foundation
- Jalmari and Rauha Ahokas Foundation
- ERANID (Understanding the Interplay between Cultural, Biological, and Subjective Factors in Drug Use Pathways) [PR-ST-0416-10004]
- BRIDGET (JPND: BRain Imaging, cognition Dementia and next generation GEnomics) [MR/N027558/1]
- MATRICS [603016]
- Innovative Medicine Initiative Project EU-AIMS [115300-2]
- Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions) [MR/N000390/1]
- Swedish Research Council FORMAS
- Medical Research Council
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- Bundesministeriumfur Bildung und Forschung (BMBF) [01GS08152, 01EV0711, eMED SysAlc01ZX1311A]
- Bundesministeriumfur Bildung und Forschung (Forschungsnetz AERIAL) [01EE1406A, 01EE1406B]
- Deutsche Forschungsgemeinschaft (DFG) [SM 80/7-2, SFB 940/2]
- Medical Research Foundation
- Medical research council [MR/R00465X/1]
- National Institutes of Health
- Science Foundation Ireland [16/ERCD/3797]
- USA (Axon, Testosterone, and Mental Health during Adolescence) [RO1 MH085772-01A1]
- NIH [U54 EB020403]
- cross-NIH alliance
- FP7 project IMAGEMEND [602450]
- Innovative Medicine Initiative Project European Autism Interventions-A Multicentre Study for Developing New Medications (EU-AIMS) [115300-2]
- Medical Research Council Programme [93558]
- Swedish funding agency Formas
- Wellcome Trust (University of Cambridge)
- Department of Health United Kingdom
- Bundesministerium fur Bildung und Forschung (BMBF) [01GS08152, 01EV0711, eMED SysAlc01ZX1311A]
- Bundesministerium fur Bildung und Forschung (BMBF) (Forschungsnetz AERIAL)
- French funding agency Agence Nationale de la Recherche (ANR) [ANR-12-SAMA-0004]
- Eranet-Neuron [AF12-NEUR0008-01-WM2NA]
- Assistance-Publique-Hopitaux-de-Paris
- Insitut national de la sante et de la recherche medicale (INSERM, interface grant)
- Paris-Descartes-University
- Paris-Sud-University (IDEX-2012)
- Fondation de France
- Intramural Research Program of the National Institute of Mental Health [ZIAMH002798]
- Horizon 2020 [695313]
- FP7 projects IMAGEMEND (IMAging GEnetics for MENtal Disorders) [602450]
- Academy of Finland (AKA) [276612, 276612] Funding Source: Academy of Finland (AKA)
- MRC [MR/R00465X/1] Funding Source: UKRI
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002798] Funding Source: NIH RePORTER
This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN). Consistently implicated in depressive disorders, the DMN's function may interact with puberty and sex in the development of these disorders, whose onsets peak in adolescence, and which show strong sex disproportionality (females > males). The main question concerns how the DMN evolves with puberty as a function of sex. These effects are expected to involve within- and between-network iFC, particularly, the salience and the central-executive networks, consistent with the Triple-Network Model. Resting-state scans of an adolescent community sample (n = 304, male/female: 157/147; mean/std age: 14.6/0.41 years), from the IMAGEN database, were analyzed using the AFNI software suite and a data reduction strategy for the effects of puberty and sex. Three midline regions (medial prefrontal, pregenual anterior cingulate, and posterior cingulate), within the DMN and consistently implicated in mood disorders, were selected as seeds. Within- and between-network clusters of the DMN iFC changed with pubertal maturation differently in boys and girls (puberty-X-sex). Specifically, pubertal maturation predicted weaker iFC in girls and stronger iFC in boys. Finally, iFC was stronger in boys than girls independently of puberty. Brain-behavior associations indicated that lower connectivity of the anterior cingulate seed predicted higher internalizing symptoms at 2-year follow-up. In conclusion, weaker iFC of the anterior DMN may signal disconnections among circuits supporting mood regulation, conferring risk for internalizing disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据