期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 8, 期 3, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.117.007392
关键词
guideline adherence; guidelines; implantable cardioverter-defibrillator; programming; remote monitoring
资金
- Boston Scientific, Inc.
Background-Inappropriate implantable cardioverter-defibrillator programming can be detrimental. Whether trials/recommendations informing best implantable cardioverter-defibrillator programming (high-rate cutoff and/or extended duration of detection) influence practice is unknown. Methods and Results-We measured reaction to publication of MADIT-RIT (Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy; 2012) and the Consensus Statement (2015) providing generic programming parameters, in a national cohort of implantable cardioverter-defibrillator recipients, using the ALTITUDE database (Boston Scientific). Yearly changes in programmed parameters to either trial-specified or class 1 recommended parameters (>= 185 beats per minute or delay >= 6 seconds) were assessed in parallel. From 2008 to 2017, 232 982 patients (aged 67 +/- 13 years; 28% women) were analyzed. Prevalence of MADIT-RIT-specific settings before publication was < 1%, increasing to 13.6% in the year following. Thereafter, this increased by < 6% over 5 years. Among preexisting implants (91 171), most patients (58 739 [64.4%]) underwent at least 1 in-person device reprogramming after trial publication, but <2% were reprogrammed to MADIT-RIT settings. Notably, prevalence of programming to >= 185 beats per minute or delay >= 6 seconds was increased by MADIT-RIT (57.4% in 2013 versus 40.2% at baseline), but the following publication of recommendations had minor incremental effect (73.2% in 2016 versus 70.8% in 2015). High-rate cutoff programming was favored almost 2-fold compared with extended duration throughout the test period. Practice changes demonstrated large interhospital and interstate variations. Conclusions-Trial publication had an immediate effect during 1 year postpublication, but absolute penetration was low, and amplified little with time. Consensus recommendations had a negligible effect. However, generic programming was exercised more widely, and increased after trial publication, but not following recommendations.
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