This study aims to evaluate whether diets containing mixture of formic and propionic acid alone or supplemented with either capric acid or Bacillus Licheniformis can alleviate immune inflammatory response of piglets challenged with enterotoxigenic Escherichia coli (ETEC). A total of 30 weaning pigs were assigned to 5 diets, without additive (CON), with antibiotics (ATB), with 1% organic acid (OA; 64% formic and 25% propionic acid), with OA plus 0.2% capric acid (OA + CRA), and with OA plus 0.02% probiotic (Bacillus Licheniformis; OA + PB). After oral challenge with ETEC on day 10, the feces and plasma of all pigs were collected at different time points. Four additive treatments all decreased rectal temperature (RT) at 9 h and fecal scores (FS) at 24 h after challenge (P < 0.05), while at 9 h after challenge, inclusion of OA induced a decrease of RT compared with OA + CRA and OA + PB (P < 0.05). In plasma, concentration of interleukin (IL)-1 beta was reduced with the addition of ATB and OA at 24 h and 48 h after challenge and it is lower in OA group than OA + CRA group at 24 h after challenge (P < 0.05). Diets with ATB, OA, and OA + PB caused a decrease of the concentrations of IL-6 in plasma at 9 h after challenge (P < 0.05). The four additives treated piglets showed decreased concentrations of plasma tumor necrosis factor-alpha and interferon-gamma at 9 h and 24 h after challenge, respectively (P < 0.05). In conclusion, OA supplementation alleviated the inflammatory response and reduced diarrhea incidence in piglets challenged with ETEC. However, no further improvements were observed when OA supplemented with CRA or probiotics.
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