期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 15, 页码 4650-4665出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201505062
关键词
3D bioprinting; biomimetics; drug discovery; tissue/organ models; toxicology
资金
- European Research Council under the European Union [615458]
- Swedish Research Council
- Erling-Persson Family Foundation
- European Research Council (ERC) [615458] Funding Source: European Research Council (ERC)
Invitro tissue/organ models are useful platforms that can facilitate systematic, repetitive, and quantitative investigations of drugs/chemicals. The primary objective when developing tissue/organ models is to reproduce physiologically relevant functions that typically require complex culture systems. Bioprinting offers exciting prospects for constructing 3D tissue/organ models, as it enables the reproducible, automated production of complex living tissues. Bioprinted tissues/organs may prove useful for screening novel compounds or predicting toxicity, as the spatial and chemical complexity inherent to native tissues/organs can be recreated. In this Review, we highlight the importance of developing 3D invitro tissue/organ models by 3D bioprinting techniques, characterization of these models for evaluating their resemblance to native tissue, and their application in the prioritization of lead candidates, toxicity testing, and as disease/tumor models.
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