Selective Oxytrifluoromethylation of Allylamines with CO2

Reported is the first oxy-trifluoromethylation of allylamines with carbon dioxide (CO2) using copper catalysis, thus leading to important CF3-containing 2-oxazolidones. It is also the first time CO2, a nontoxic and easily available greenhouse gas, has been used to tune the difunctionalization of alkenes from amino-to oxy-trifluoromethylation. Of particular note, this multicomponent reaction is highly chemo-, regio-, and diastereoselective under redox-neutral and mild reaction conditions. Moreover, these reactions feature good functional-group tolerance, broad substrate scope, easy scalability and facile product diversification. The important products could also be formed with either spirocycles or two adjacent tetrasubstituted carbon centers.