期刊
WILEY INTERDISCIPLINARY REVIEWS-RNA
卷 10, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/wrna.1529
关键词
3 ' end processing; capping; co-transcriptional; quality control; RNA processing; RNAPII; splicing; termination; transcription
类别
资金
- National Heart and Lung Institute [T32 HL007910]
- National Institute of General Medical Sciences [GM099714]
- National Science Foundation [MCB 1515748]
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3 ' end processing of different RNA species to help ensure quality control of the transcriptome. Many improperly processed transcripts are not exported from the nucleus, are restricted to the site of transcription, and are in some cases degraded, which helps to limit any possibility of aberrant RNA causing harm to cellular health. These critical quality control pathways are regulated by the highly dynamic protein-protein interaction network at the site of transcription. Recent work has further revealed the extent to which the processes of transcription and RNA processing and quality control are integrated, and how critically their coupling relies upon the dynamic protein interactions that take place co-transcriptionally. This review focuses specifically on the intricate balance between 3 ' end processing and RNA decay during transcription termination. This article is categorized under: RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Processing > 3' End Processing RNA Processing > Splicing Mechanisms RNA Processing > Capping and 5' End Modifications
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