期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 13, 页码 4308-4311出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201512018
关键词
alkenes; amides; annulation; C-H activation; cobalt
资金
- Ministry of Science and Technology of the Republic of China [MOST-104-2633-M-007-001]
A highly diastereoselective method for the synthesis of dihydroepoxybenzofluorenone derivatives from aromatic/vinylic amides and bicyclic alkenes is described. This new transformation proceeds through cobalt-catalyzed C-H activation and intramolecular nucleophilic addition to the amide functional group. Transition-metal-catalyzed C-H activation reactions of secondary amides with alkenes usually lead to [4+2] or [4+1] annulation; to the best of our knowledge, this is the first time that a [3+2] cycloaddition is described in this context. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. Mechanistic studies imply that the C-H bond cleavage may be the rate-limiting step.
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