期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 32, 页码 9384-9388出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201603943
关键词
carbocyclization; C-H activation; enaminones; naphthalenes; rhodium
资金
- National Natural Science Foundation of China [21425415, 21274058]
- National Basic Research Program of China [2015CB856303]
The use of enaminones as effective synthons for a directed C-H functionalization is reported. Proof-of-concept protocols have been developed for the Rh-III-catalyzed synthesis of naphthalenes, based on the coupling of enaminones with either alkynes or alpha-diazo-beta-ketoesters. Two inherently reactive functionalities (hydroxy and aldehyde groups) are integrated into the newly formed cyclic framework and a broad range of substituents are tolerated, rendering target products readily available for further elaboration.
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