期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 1, 页码 364-367出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201606637
关键词
asymmetric catalysis; C-H activation; chiral Cp ligands; P-chirality; rhodium
资金
- European Research Council (ERC) [257891]
- Swiss National Science Foundation [157741]
- European Research Council (ERC) [257891] Funding Source: European Research Council (ERC)
Compounds with stereogenic phosphorus atoms are frequently used as ligands for transition-metal as well as organocatalysts. A direct catalytic enantioselective method for the synthesis of P-chiral compounds from easily accessible diaryl phosphinamides is presented. The use of rhodium(III) complexes equipped with a suitable atropochiral cyclopentadienyl ligand is shown to enable an enantiodetermining C-H activation step. Upon trapping with alkynes, a broad variety of cyclic phosphinamides with a stereogenic phosphorus(V) atom are formed in high yields and enantioselectivities. Moreover, these can be reduced enantiospecifically to P-chiral phosphorus(III) compounds.
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