期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 23, 页码 6646-6650出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201600868
关键词
antioxidant defense system; nanozymes; oxidative stress; reactive oxygen species; self-assembly
资金
- National Basic Research Program of China [2012CB720602]
- National Natural Science Foundation of China [21210002, 21431007, 21403209, 21533008]
In this work, for the first time, we constructed a novel multi-nanozymes cooperative platform to mimic intracellular antioxidant enzyme-based defense system. V2O5 nanowire served as a glutathione peroxidase (GPx) mimic while MnO2 nanoparticle was used to mimic superoxide dismutase (SOD) and catalase (CAT). Dopamine was used as a linker to achieve the assembling of the nanomaterials. The obtained V2O5@pDA@MnO2 nanocomposite could serve as one multi-nanozyme model to mimic intracellular antioxidant enzyme-based defense procedure in which, for example SOD, CAT, and GPx co-participate. In addition, through assembling with dopamine, the hybrid nanocomposites provided synergistic antioxidative effect. Importantly, both in vitro and in vivo experiments demonstrated that our biocompatible system exhibited excellent intracellular reactive oxygen species (ROS) removal ability to protect cell components against oxidative stress, showing its potential application in inflammation therapy.
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