期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 6, 页码 2101-2106出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201510031
关键词
antitumor agents; cancer; Fenton reaction; iron nanoparticles; magnetic resonance imaging
资金
- National Natural Science Foundation of China [51372260, 51132009]
- Natural Science Foundation of Shanghai [15ZR1407700]
Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H2O2 in a tumor microenvironment: Ionization of the AFeNPs enables on-demand ferrous ion release in the tumor, and subsequent H2O2 disproportionation leads to efficient (OH)-O-. generation. The endogenous stimuli-responsive (OH)-O-. generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input.
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