期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 17, 页码 5304-5308出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201600911
关键词
chiral resolution; enantioselective recognition; host-guest chemistry; macrocycles; triptycenes
资金
- National Natural Science Foundation of China [21332008, 91527301, 21521002]
- Strategic Priority Research Program of CAS [XDB12010400]
A new class of chiral macrocyclic arene composed of three chiral 2,6-dihydroxyltriptycene subunits bridged by methylene groups was designed and synthesized. Structural studies showed that the macrocyclic molecule adopts a hex-nut-like structure with a helical chiral cavity and highly fixed conformation. Efficient resolution was achieved through the introduction of chiral auxiliaries to give a couple of enantiopure macrocycles, which exhibited high enantioselectivity towards three pairs of chiral compounds containing a trimethylamino group.
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