期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 20, 页码 6093-6098出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201510497
关键词
C-O bond activation; C-C cross-coupling; cross-coupling; nickel; trialkylaluminum
资金
- China Scholarship Council
- DAAD fellowship
- Kekule fellowship (Fonds der Chemischen Industrie)
- Studienstiftung des deutschen Volkes
In the presence of trialkylaluminum reagents, diverse aryl methyl ethers can be transformed into valuable products by C-O bond-cleaving alkylation, for the first time without the limiting -hydride elimination. This new nickel-catalyzed dealkoxylative alkylation method enables powerful orthogonal synthetic strategies for the transformation of a variety of naturally occurring and easily accessible anisole derivatives. The directing and/or activating properties of aromatic methoxy groups are utilized first, before they are replaced by alkyl chains in a subsequent coupling process.
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