期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 1, 页码 306-309出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201608210
关键词
bromination; C-H functionalization; copper; radical H-abstraction; synthetic methods
资金
- Scripps Research Institute
- NSF [CHE-1205646]
- Bristol-Myers Squibb
Selective bromination of gamma-methylene C(sp(3))-H bonds of aliphatic amides and delta-methylene C(sp(3))-H bonds of nosyl-protected alkyl amines are developed using NBS as the brominating reagent and catalytic amount of Cu-II/phenanthroline complexes as the catalyst. Aryl and benzylic C II bonds at other locations remain intact during this directed radical abstraction reaction.
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