期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 52, 页码 16145-16148出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201609929
关键词
deep eutectic solvents; green chemistry; imines; organolithium reagents; salt activation
资金
- Spanish MINECO [RYC-2011-08451, CTQ2013-40591-P, CTQ2014-51912-REDC]
- Gobierno del Principado de Asturias [GRUPIN14-006]
- EU COST [SIPs-CM1302]
- MINECO
- European Social Fund
- ERC (Stg MixMetApps)
Shattering the long-held dogma that organolithium chemistry needs to be performed under inert atmospheres in toxic organic solvents, chemoselective addition of organolithium reagents to non-activated imines and quinolines has been accomplished in green, biorenewable deep eutectic solvents (DESs) at room temperature and in the presence of air, establishing a novel and sustainable access to amines. Improving on existing methods, this approach proceeds in the absence of additives; occurs without competitive enolization, reduction or coupling processes; and reactions were completed in seconds. Comparing RLi reactivities in DESs with those observed in pure glycerol or THF suggests a kinetic anionic activation of the alkylating reagents occurs, favoring nucleophilic addition over competitive hydrolysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据