期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2019.00060
关键词
Hapln2; aggregates; Parkinson's disease; Alzheimer's disease; schizophrenia
资金
- Supporting Fund for Teachers' research of Jining Medical University [JY2017KJ036]
- Research Fund for the Doctoral Program of Jining Medical University
- Project of Shandong Province Higher Educational Science and Technology Program [J18KA124]
- Research Fund for Lin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University [JYHL2018MS03]
- National Nature Science Foundation of China [81501018]
- Natural Science Foundation of Shandong Province [ZR2018MC005]
- Science and Technology plan project of Shandong higher education institutions [J15LE19]
Hyaluronan and proteoglycan link protein 2 (Hapln2) is important for the binding of chondroitin sulfate proteoglycans to hyaluronan. Hapln2 deficiency leads to the abnormal expression of extracellular matrix (ECM) proteins and dysfunctional neuronal conductivity, demonstrating the vital role of Hapln2 in these processes. Studies have revealed that Hapln2 promotes the aggregation of alpha-synuclein, thereby contributing to neurodegeneration in Parkinson's disease (PD), and it was recently suggested to be in intracellular neurofibrillary tangles (NFTs). Additionally, the expression levels of Hapln2 showed lower in the anterior temporal lobes of individuals with schizophrenia than those of healthy subjects. Together, these studies implicate the involvement of Hapln2 in the pathological processes of neurological diseases. A better understanding of the function of Hapln2 in the central nervous system (CNS) will provide new insights into the molecular mechanisms of these diseases and help to establish promising therapeutic strategies. Herein, we review the recent progress in defining the role of Hapln2 in brain physiology and pathology.
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