期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2019.00015
关键词
aging; brain energy metabolism; cognition; glucose; insulin resistance; ketones
资金
- Fonds de recherche QuebecSante
- NSERC
- Canada Research Chairs Secretariat
- Universite de Sherbrooke Research Chair
We aimed to longitudinally assess the relationship between changing brain energy metabolism (glucose and acetoacetate) and cognition during healthy aging. Participants aged 71 +/- 5 year underwent cognitive evaluation and quantitative positron emission tomography (PET) and magnetic resonance imaging (MRI) scans at baseline (N = 25) and two (N = 25) and four (N = 16) years later. During the follow-up, the rate constant for brain extraction of glucose (K-glc) declined by 6%-12% mainly in the temporo-parietal lobes and cingulate gyri (p <= 0.05), whereas brain acetoacetate extraction (Kacac) and utilization remained unchanged in all brain regions (p >= 0.06). Over the 4 years, cognitive results remained within the normal age range but an age-related decline was observed in processing speed. K-glc , in the caudate was directly related to performance on several cognitive tests (r = +0.41 to +0.43, all p <= 0.04). Peripheral insulin resistance assessed by the homeostasis model assessment of insulin resistance (HOMA-IR) was significantly inversely related to K-glc , in the thalamus (r = -0.44, p = 0.04) and in the caudate (r = -0.43, p = 0.05), and also inversely related to executive function, attention and processing speed (r = -0.45 to -0.53, all p <= 0.03). We confirm in a longitudinal setting that the age-related decline in K-glc is directly associated with declining performance on some tests of cognition but does not significantly affect Kacac.
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