期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 33, 页码 9743-9747出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201604406
关键词
arenes; cross-coupling; deuterium; methylation; nickel
资金
- Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases
- Tsinghua-Peking Centre for Life Sciences
- 1000 Talents Recruitment Program
A nickel-catalyzed methylation of aryl halides with cheap and readily available CH3I or CD (3) I is described. The reaction is applicable to a wide range of substrates and allows installation of a CD3 group under mild reaction conditions without deuterium scrambling to other carbon atoms. Initial mechanistic studies on the stoichiometric and catalytic reactions of the isolated [(dppp)Ni(C6H4-4-CO2Et)Br] [dppp= 1,3-bis(diphenylphosphanyl)propane] suggest that a Ni-0/ Ni-II catalytic cycle is favored.
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