期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 12, 页码 4035-4039出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201511002
关键词
C-H activation; cobalt; indoles; reaction mechanisms; regioselectivity
资金
- National Basic Research Program of China (973 Program) [2015CB856600]
- National Natural Science Foundation of China [21325206, 21172006]
- National Young Top-notch Talent Support Program
The unique regioselectivity and reactivity of cobalt(III) in the direct cyclization of N-nitrosoanilines with alkynes for the expedient synthesis of N-substituted indoles is demonstrated. In the presence of a cobalt(III) catalyst, high regioselectivity was observed when using unsymmetrical meta-substituted N-nitrosoanilines. Moreover, internal alkynes bearing electron-deficient groups, which are almost unreactive in the [Cp*Rh-III]-catalyzed system, display good reactivity in this transformation.
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