期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 25, 页码 7152-7156出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602569
关键词
C-H functionalization; C-N coupling; copper catalysis; hypervalent iodine; imidazoles
资金
- Fundacio ICIQ
- MINECO [CTQ2013-46705-R, CTQ2014-54071-P]
- MINECO (Severo Ochoa Excellence Accreditation) [SEV-2013-0319]
- Generalitat de Catalunya [2014 SGR 1192]
- CELLEX Foundation through the CELLEX-ICIQ HTE platform
The synthesis of N-arylimidazoles substituted at the sterically encumbered 5-position is a challenge for modern synthetic approaches. A new family of imidazolyl aryliodonium salts is reported, which serve as a stepping stone on the way to selective formation of N1-aryl-5-iodoimidazoles. Iodine acts as a universal placeholder poised for replacement by aryl substituents. These new lambda(3)-iodanes are produced by treating the NH-imidazole with ArI(OAc)(2), and are converted to N1-aryl-5-iodoimidazoles by a selective copper-catalyzed aryl migration. The method tolerates a variety of aryl fragments and is also applicable to substituted imidazoles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据