期刊
CELL REPORTS
卷 26, 期 11, 页码 2955-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2019.02.050
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资金
- NIH/NINDS [RO1 AG057575-01]
- NIH/NIA
- Novo Nordisk Foundation
- Lundbeck Foundation
- Adelson Medical Research Foundation
- European Union (EU) Joint Programme - Neurodegenerative Disease Research (JPND) program
- EU Horizon 2020 Research and Innovation Program grant [643417/DACAPO-AD]
- Swedish Science Council VR [2015-00550]
- Swedish Cancer Foundation [CF 15 0735]
- Knut & Alice Wallenberg Foundation [2015.0030]
- Swedish Research Council [2015-00550] Funding Source: Swedish Research Council
- Formas [2015-00550] Funding Source: Formas
The glymphatic system is a highly polarized cerebro-spinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently co-incided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb(ret/ret) suppressed the development of the glymphatic system, whose functions remained suppressed in adulthood compared with wild-type mice. These experiments map the natural development of the glymphatic system in mice and define a critical role of PDGF-B in the development of perivascular CSF transport.
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