期刊
CELL REPORTS
卷 26, 期 11, 页码 3027-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2019.02.056
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资金
- German Ministry of Education and Research (BMBF: DZD) [82DZD00302]
- German Diabetes Association (DDG) [2017/02/21]
- German Research Foundation (DFG) [SFB-958]
- Swedish Research Council
- Novo Nordisk Foundation
- Linne grant [B31 5631/2006]
- JDRF [1-2008-416]
- EXODIAB Human Tissue Lab, Lund University
- State of Brandenburg
An insufficient adaptive beta-cell compensation is a hallmark of type 2 diabetes (T2D). Primary cilia function as versatile sensory antennae regulating various cellular processes, but their role on compensatory beta-cell replication has not been examined. Here, we identify a significant enrichment of downregulated, cilia-annotated genes in pancreatic islets of diabetes-prone NZO mice as compared with diabetes-resistant B6-ob/ob mice. Among 327 differentially expressed mouse cilia genes, 81 human orthologs are also affected in islets of diabetic donors. Islets of nondiabetic mice and humans show a substantial overlap of upregulated cilia genes that are linked to cell-cycle progression. The shRNA-mediated suppression of KIF3A, essential for ciliogenesis, impairs division of MINE beta cells as well as in dispersed primary mouse and human islet cells, as shown by decreased BrdU incorporation. These findings demonstrate the substantial role of cilia-gene regulation on islet function and T2D risk.
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