期刊
CELL REPORTS
卷 26, 期 5, 页码 1157-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2019.01.031
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资金
- Nina Ireland [NIMH R01 MH081880, NIMH R37/R01 MH04942]
- UCSF CTSI [1111111]
- Alliance Funds
- UCSF neuroscience graduate program
- National Science Foundation [1650113, 1608234]
- NINDS [5R00NS078118-04, 5R01NS096369-02]
- Department of Defense [EP150038]
- Gladstone Institutes
Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST+ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.
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