期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 40, 页码 12270-12274出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201606458
关键词
boron; cross-coupling; fluorine; nickel; synthetic methods
资金
- National Basic Research Program of China (973 Program) [2012CB821600, 2015CB931900]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20020000]
- National Natural Science Foundation of China [21425208, 21332010, 21421002, 21672238]
- SIOC
A nickel-catalyzed three-component reaction for the synthesis of difluoroalkylated compounds through tandem difluoroalkylation-arylation of enamides has been developed. The reaction tolerates a variety of arylboronic acids and widely available difluoroalkyl bromides, and even the relatively inert substrate chlorodifluoroacetate. The significant advantages of this protocol are the low-cost nickel catalyst, synthetic convenience, excellent functional-group compatibility and high reaction efficiency.
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