期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 19, 页码 5809-5813出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201511047
关键词
carbenes; cycloaddition; diazo compounds; homogenous catalysis; pyridinium ylides
资金
- EPSRC [EP/J021008/1]
- AstraZeneca
- University of Nottingham
- Engineering and Physical Sciences Research Council [EP/J021008/1, 1069372] Funding Source: researchfish
- EPSRC [EP/J021008/1] Funding Source: UKRI
Commercially available iron(III) and copper(I) complexes catalyzed multicomponent cycloaddition reactions between diazo compounds, pyridines, and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yield with high diastereoselectivity. Hitherto, the catalytic formation of versatile pyridinium ylides from metal carbenes has been poorly developed; the broad utility demonstrated herein sets the stage for the invention of further multicomponent reactions in future.
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