期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 1, 页码 354-358出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201610014
关键词
annulation; borylation; cross coupling; electrophilic cyclization; organoboranes
资金
- ERC under framework 7 [305868]
- Royal Society
- EPSRC [EP/K039547/1]
- Engineering and Physical Sciences Research Council [EP/K039547/1] Funding Source: researchfish
- EPSRC [EP/K039547/1] Funding Source: UKRI
BCl3-induced borylative cyclization of aryl-alkynes possessing ortho-EMe (E = S, O) groups represents a simple, metal-free method for the formation of C3-borylated benzothiophenes and benzofurans. The dichloro(heteroaryl) borane primary products can be protected to form synthetically ubiquitous pinacol boronate esters or used in situ in SuzukiMiyaura cross couplings to generate 2,3-disubstituted heteroarenes from simple alkyne precursors in one pot. In a number of cases alkyne trans-haloboration occurs alongside, or instead of, borylative cyclization and the factors controlling the reaction outcome are determined.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据