期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 23, 页码 6744-6748出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601928
关键词
alkynes; enantioselective; fluorine; organocatalysts; silicon
资金
- Platform Project for Supporting in Drug Discovery and Life Science Research from MEXT
- Japan Agency for Medical Research and Development (AMED)
- Advanced Catalytic Transformation (ACT-C) from JST Agency
Asymmetric methods for preparation of chiral alkynyl-containing compounds are in extremely high demand in many sectors of chemical research. In this work, we report the discovery of a general organocatalytic enantioselective alkynylation based on the idea of Si/F activation of the allylic C-F bond. This approach features reasonably broad substrate scope, functional group tolerance, and relatively neutral, mild, and operationally convenient reaction conditions; all of which bode well for the synthetic value of the discovered method. In particular, this method provides unique chiral skipped 1,4-eneynes having two kinds of versatile functional groups.
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