期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 28, 页码 7988-7992出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602219
关键词
asymmetric hydrogenation; enamides; iridium; ligand design; P ligands
资金
- Spanish MINECO [CTQ2014-56361-P]
- IRB Barcelona
- Generalitat de Catalunya
- MINECO
- Severo Ochoa Award of Excellence from MINECO (Government of Spain)
The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the reduction of cyclic enamides derived from alpha-and beta-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: In most cases, a decrease in the H-2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and ethyl acetate, with no loss of selectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据