期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 32, 页码 9282-9286出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602610
关键词
copolymerization; degradation; hydrogels; polymers; swelling
资金
- JSPS [24240069, 25708033, 26870166, 14J06051]
- Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program)
- MEXT, Japan through Graduate Program for Leaders in Life Innovation (GPLLI)
- Center for Medical System Innovation (CMSI)
- Center for NanoBio Integration (CNBI)
- JST
- Center of Innovation (COI) Program
- PRESTO
- Grants-in-Aid for Scientific Research [16H05972, 14J06051, 26870166, 25708033] Funding Source: KAKEN
Hydrogels are promising materials for biomedical applications, where timely degradation is often preferred. In the conventional design, however, the cleavage of polymer networks essentially causes considerable morphological changes (i.e., degradation-induced swelling), triggering various medical complications. Herein, we report a rational strategy to suppress the degradation-induced swelling based on the synthetic control of the polymer-solvent interaction parameter (chi) of constituent polymer networks. The resultant hydrogels with an optimal chi parameter (chi(37 degrees C)approximate to 0.53; nonosmostic hydrogels) displayed the capability to retain their original shape and degrade without generating significant swelling pressure under physiological conditions (Pi(37 degrees C)<1 kPa). This concept of the safely degradable non-osmotic hydrogel is theoretically universal, and can be exploited for other types of synthetic hydrogels in various settings.
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