期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 30, 页码 8610-8614出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602965
关键词
antibiotics; Gram specificity; ligands; nanoparticles; surface charge
资金
- Non-Equilibrium Energy Research Center (NERC), which is an EFRC center - U.S. Department of Energy [DE-SC0000989]
- NIH [1R21CA137707-01, U54CA119341]
- Institute for Basic Science Korea [IBS-R020-D1]
Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram-selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [-] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non-covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/-] nanoparticles are effective in low doses, are non-toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro) molecular level.
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