期刊
SCIENTIFIC REPORTS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-019-39441-6
关键词
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资金
- National Institutes of Health [R01-DK-102896]
- official funding agency for biomedical research of the Spanish government
- Instituto de Salud Carlos III [RTIC G03/140, RTIC RD 06/0045]
- Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion
- Centro Nacional de Investigaciones Cardiovasculares [CNIC 06/2007]
- Fondo de Investigacion Sanitaria Fondo Europeo de Desarrollo Regional [PI04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505, PI13/00462]
- Ministerio de Ciencia e Innovacion [AGL-2009-13906-C02, AGL2010-22319-C03]
- Fundacion Mapfre 2010
- Consejeria de Salud de la Junta de Andalucia [PI0105/2007]
- Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana [ACOMP06109, GVA-COMP2010-181, GVACOMP2011-151, CS2010-AP-111, CS2011-AP-042]
- Regional Government of Navarra [P27/2011]
- Generalitat Valenciana [PROMETEO17/2017]
- Fundacio la Marato-TV3 [538/U/2016]
- Autonomous Government of Catalonia (PERIS 2016-2020 INCORPORACIO DE CIENTIFICAS I TECNOLEGS) [SLT002/0016/00428]
- Lilly Foundation European Association of Diabetes (EASD) through Institut d'Investigacions Sanitaries Pere i Virgili (IISPV), Tarragona, Spain
Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.
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