期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 24, 页码 6938-6941出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601296
关键词
alkyl halides; alkynes; boron; nickel; radicals
资金
- European Research Council (ERC) [307948]
- Swiss National Science Foundation [200020_146853]
- Swiss National Science Foundation (SNF) [200020_146853] Funding Source: Swiss National Science Foundation (SNF)
Anickel-catalyzed three-component reaction involving terminal alkynes, boronic acids, and alkyl halides is presented herein. Trisubstituted alkenes can be obtained in a highly regio- and stereocontrolled manner by the simultaneous addition of both aryl and alkyl groups across the triple bond in a radical-mediated process. The reaction, devoid of air- and moisture-sensitive organometallic reagents and catalysts, is operationally simple and offers a broad scope and functional-group tolerance.
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