期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 29, 页码 8216-8226出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201600010
关键词
C-C coupling; CO activation; interstitial carbide; nitrogenases; radicals
资金
- NIH [GM-67626]
- DOE (BES) [DE-SC0014470]
- Hellman foundation
- U.S. Department of Energy (DOE) [DE-SC0014470] Funding Source: U.S. Department of Energy (DOE)
Named after its ability to catalyze the reduction of nitrogen to ammonia, nitrogenase has a surprising rapport with carbon-both through the interstitial carbide that resides in the central cavity of its cofactor and through its ability to catalyze the reductive carbon-carbon coupling of small carbon compounds into hydrocarbon products. Recently, a radical-SAM-dependent pathway was revealed for the insertion of carbide, which signifies a novel biosynthetic route to complex bridged metalloclusters. Moreover, a sulfur-displacement mechanism was proposed for the activation of carbon monoxide by nitrogenase, which suggests an essential role of the interstitial carbide in maintaining the stability while permitting a certain flexibility of the cofactor structure during substrate turnover.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据