期刊
NUTRIENTS
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/nu11010209
关键词
sucrose overfeeding; hepatic steatosis; intramyocellular lipids; intrahepatocellular lipids; dietary protein content; dietary fat content; energy expenditure; plasma triglyceride
资金
- Swiss National Foundation for science [32003B 156167]
- Institute Benjamin Delessert Foundation
- Swiss National Science Foundation (SNF) [32003B_156167] Funding Source: Swiss National Science Foundation (SNF)
Sucrose overfeeding increases intrahepatocellular (IHCL) and intramyocellular (IMCL) lipid concentrations in healthy subjects. We hypothesized that these effects would be modulated by diet protein/fat content. Twelve healthy men and women were studied on two occasions in a randomized, cross-over trial. On each occasion, they received a 3-day 12% protein weight maintenance diet (WM) followed by a 6-day hypercaloric high sucrose diet (150% energy requirements). On one occasion the hypercaloric diet contained 5% protein and 25% fat (low protein-high fat, LP-HF), on the other occasion it contained 20% protein and 10% fat (high protein-low fat, HP-LF). IHCL and IMCL concentrations (magnetic resonance spectroscopy) and energy expenditure (indirect calorimetry) were measured after WM, and again after HP-LF/LP-HF. IHCL increased from 25.0 +/- 3.6 after WM to 147.1 +/- 26.9 mmol/kg wet weight (ww) after LP-HF and from 30.3 +/- 7.7 to 57.8 +/- 14.8 after HP-LF (two-way ANOVA with interaction: p < 0.001 overfeeding x protein/fat content). IMCL increased from 7.1 +/- 0.6 to 8.8 +/- 0.7 mmol/kg ww after LP-HF and from 6.2 +/- 0.6 to 6.9 +/- 0.6 after HP-LF, (p < 0.002). These results indicate that liver and muscle fat deposition is enhanced when sucrose overfeeding is associated with a low protein, high fat diet compared to a high protein, low fat diet.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据