期刊
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
卷 28, 期 9, 页码 1011-1017出版社
WILEY
DOI: 10.1111/jopr.13032
关键词
C. albicans attachment; poly methyl methacrylate resin; surface characterization; titanium dioxide coating
资金
- NSF [CBET 1067424]
- Wach Dental Research Fund, COD, UIC
Purpose: The objective of this study was to improve the surface characteristics of poly (methyl methacrylate) (PMMA) by developing a novel, thin film coating process and to characterize the resulting coated surface. Materials and Methods: An atomic layer deposition (ALD) technique was developed to deposit a titanium dioxide (TiO2) nano-thin film on PMMA. The surface wettability for both coated and uncoated PMMA was determined by measuring water contact angle. Wear resistance was assessed using a mechanical tooth-brushing device with a 50 g load for 6000 strokes after 5 months of water storage. A denture cleanser challenge test was performed by using sonication in 3.8% sodium perborate for 1 hour with aged specimens. X-ray photoelectron spectroscopy (XPS) was used before and after the brushing test and challenge test to analyze the PMMA surface chemical composition. The mechanical strength of coated and uncoated PMMA was measured using a three-point bending test. Surface microbial interactions were also evaluated by assessing Candida albicans biofilm attachment. Results: Nano-TiO2 coating (30 nm thick) was successfully deposited on PMMA at 65 degrees C. After coating, water contact angle decreased from 70 degrees to less than 5 degrees. After brushing test, the coating remained intact. XPS analysis revealed no loss of TiO2 from coated specimens following brushing and denture cleanser sonication for 1 hour. There was no statistically significant difference in mechanical strength (MPa) (mean +/- SD) between PMMA (139.4 +/- 11.3) and TiO2-PMMA (160.7 +/- 37.1) (p = 0.0995). C. albicans attachment decreased by 63% to 77% on the coated PMMA surface. Conclusions: ALD is a promising technique to modify surface properties of PMMA and resulted in a stable adherent thin film. By depositing a TiO2 coating, PMMA surface properties may lead to significantly reduced microorganism adhesion and easier pathogen removal from PMMA. For patients who wear dentures, reducing the oral microbial biofilm burden using a TiO2-coated PMMA surface could positively impact their oral and systemic health.
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