期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 31, 页码 8904-8908出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602936
关键词
drug delivery; flufenamic acid; mesoporous silica; nanocrystals; solid-state NMR spectroscopy
资金
- University of East Anglia
- EPSRC Directed Assembly Network
- EPSRC CASE studentship - EPSRC
- Bristol-Myers Squibb [EP/I501517/1]
- EPSRC [EP/J007803/1]
- EPSRC [EP/J007803/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [1039855, EP/J007803/1] Funding Source: researchfish
The introduction of fluorine into the structure of pharmaceuticals has been an effective strategy for tuning their pharmacodynamic properties, with more than 40 new drugs entering the market in the last 15 years. In this context, F-19 NMR spectroscopy can be viewed as a useful method for investigating the host-guest chemistry of pharmaceuticals in nanosized drug-delivery systems. Although the interest in confined crystallization, nanosized devices, and porous catalysts is gradually increasing, understanding of the complex phase behavior of organic molecules confined within nanochambers or nanoreactors is still lacking. Using F-19 magicangle-spinning NMR spectroscopy, we obtained detailed mechanistic insight into the crystallization of flufenamic acid (FFA) in a confined environment of mesoporous silica materials with different pore diameters (3.2-29 nm), providing direct experimental evidence for the formation of a molecular-liquid-like layer besides crystalline confined FFA form I.
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